Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

Blog Article

Abstract MicroRNA (miRNA) plays a key role in virus-host interactions.Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus here (AIV).A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs.Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling Wooden Toy pathways.These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.